Expand precision medicine to the rest of the genome
Nearly all current DNA biomarkers exist as mutations in expressed genes, constituting only about 2% of the genome. BreakSight aims to expand the effective coverage of therapeutically-relevant DNA sequences to the remaining 98% of the genome.
Precision Medicine
Discover your drug’s effect on the genome
Cancer Research
Reveal genome-wide patterns of damage
Uncover patterns of genomic instability that drive tumor progression or that sensitizes the cancer to different targeted approaches.
Drug Development
Enhance target assessment and discovery
Evaluate drug efficacy, optimize dosing strategies, and discover new targets to enhance the precision and effectiveness of emerging treatments.
Genomic Instability
Identify mutations and vulnerabilities across non-coding regions of the genome
Advance basic biology research and create hypothesis-generating data that leads to unique genomic discoveries and a better understanding of the mechanisms of DNA damage and repair.
Biomarker Discovery
Unlock the rest of the genome to expand biomarker identification
Identify novel biomarkers, understand drug mechanisms, and discover new therapeutic targets
Our Technology
At the forefront of precision medicine and targeted therapy
From DNA break mapping with DDsite to comprehensive bioinformatics analysis with DDinsight, BreakSight provides a complete workflow tailored for therapeutics development.
DDsite and DDsite-Cyto
DDsite enables precise tagging and retrieval of DNA double-strand break sites across the genome, ideal for cells exposed to DNA-damaging treatments. The service includes library preparation, quality control, and next-generation sequencing (150 bp paired-end).
With DDsite-Cyto, capture and analyze cytoplasmic DNA breaks, separately from nuclear DNA breaks. These identified DNA sequences hold promise to predict synergy with immunotherapies.
DDinsight and DDinsight+
DDinsight analyzes sequenced data to identify reproducible DNA break sites specific to your treatment conditions and compares break patterns across treatments.
With DDinsight+, uncover enriched DNA repeats, sequence motifs, and link break sites to genome-wide elements using publicly available databases for deeper insights.
Resources
Explore our research
Have questions?
contact us
Contact us
