How it works
Reveal genomic sequences and regions associated with DNA damage.
Trimming
Removes low-quality or adapter sequences for cleaner data.
Quality Checks
Ensures high data integrity and reliability.
Alignment
Maps sequenced reads to the reference genome for analysis.
Peak-Calling
Identifies significant DNA break sites.
Basic Peak Annotations
Categorizes identified DNA break peaks by their genomic locations, such as introns, exons, promoters, and simple repeats
Data Report
Summarizes findings with detailed insights and visuals.
IDR (Irreproducible Discovery Rate)
Validates reproducibility of identified break sites.
Coverage Plot Generation
Allows for visualization of mapped sequence reads and DNA break peaks along the chromosomes.
DDinsight+
Explore complex mechanisms of genomic instability
- Uncover DNA repeats and sequence motifs enriched at break sites.
- Associate identified DNA break sites with publicly available databases of genome-wide elements (e.g. ChIP-Seq data, gene regions, histone marks, etc.)
