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sample analysis
DDinsight and DDinsight+

Detailed reports. Actionable insights

DDinsight processes and analyzes sequenced data to identify reproducible DNA break sites, compare treatment effects, and pinpoint enriched DNA motifs or repeats.

How it works

Reveal genomic sequences and regions associated with DNA damage.

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Trimming

Removes low-quality or adapter sequences for cleaner data.

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Quality Checks

Ensures high data integrity and reliability.

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Alignment

Maps sequenced reads to the reference genome for analysis.

An icon of a broken DNA strand.

Peak-Calling

Identifies significant DNA break sites.

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Basic Peak Annotations

Categorizes identified DNA break peaks by their genomic locations, such as introns, exons, promoters, and simple repeats

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Data Report

Summarizes findings with detailed insights and visuals.

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IDR (Irreproducible Discovery Rate)

Validates reproducibility of identified break sites.

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Coverage Plot Generation

Allows for visualization of mapped sequence reads and DNA break peaks along the chromosomes.

DDinsight+
Explore complex mechanisms of genomic instability
  • Uncover DNA repeats and sequence motifs enriched at break sites.
  • Associate identified DNA break sites with publicly available databases of genome-wide elements (e.g. ChIP-Seq data, gene regions, histone marks, etc.)
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